We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
Read More
7
Antioxidants may aid cardiovascular health
Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
Read More
7
Selenium may reduce platelet function
Effects of sodium selenite on in vitro interactions between platelets and endothelial cells.
Our study explored how selenium influences the interaction between platelets and endothelial cells, especially regarding blood clot formation. We noticed that selenium supplementation increased the activity of protective enzymes in both platelets and endothelial cells.
Interestingly, we found that platelets showed reduced aggregation in the presence of selenium-rich endothelial cells. However, this effect was nullified when we used aspirin, indicating a complex relationship. Ultimately, while selenium shows promise, we did not find significant improvements in nitric oxide levels linked to clot prevention.
Read More
Most Useful Reviews
9
Blood sugar control
It has a considerable impact on managing blood sugar and has been repurchased multiple times. By taking NAC and cinnamon together, I have halted blood sugar medication and maintained my fasting blood sugar below 6. Highly recommended.
Read More
9
Life-changing results
5 people found this helpful
This has greatly reduced my high blood pressure and cholesterol! I discovered it through my brother and, due to a chaotic work schedule, I struggled with nutrition. NAC Detox Regulators have proven to be the best option. I have been taking it daily for a year, and my health reports show significant improvement in my blood pressure and cholesterol. I highly recommend it – it has genuinely improved my life.
Read More
9
Natto benefits
Great! Excellent quality and dosage. I recommend it to everyone, especially those dealing with blood clots or thrombosis. Natto significantly "gnaws" at blood clots, though large dosages are required over a prolonged period.
We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
Read More
9.5
Ebselen delays blood clot formation
Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression.
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
Read More
9
Selenium polymer reduces blood clots
Multifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications.
We explored the effectiveness of a new polymer infused with selenium in tackling blood clots and infections associated with medical devices. This SNAP-Se-1 composite works by releasing nitric oxide (NO), a natural defender against both issues. We found that it remarkably reduced platelet adhesion by 85.5% while also displaying antibacterial properties. Importantly, this innovative approach minimizes the need for traditional antibiotic treatments. Overall, while we see promising results in lab settings, further research is needed to confirm these benefits in real-world applications.
Read More
8
Enhanced imaging for carotid thrombosis
High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging.
We investigated how selenium-based nanomaterials boost photoacoustic imaging to identify carotid artery blood clots more effectively. By using a thrombosis model in mice, we found that these nanocomposites significantly enhanced imaging signals—up to 5 times greater—which helps diagnose the extent of carotid atherosclerosis.
This research suggests that selenium/polypyrrole nanoparticles may be a promising tool for improving the detection and diagnosis of carotid thrombosis, potentially leading to better stroke prevention strategies.
Read More
7
Antioxidants may aid cardiovascular health
Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
It has a considerable impact on managing blood sugar and has been repurchased multiple times. By taking NAC and cinnamon together, I have halted blood sugar medication and maintained my fasting blood sugar below 6. Highly recommended.
Read More
9
Life-changing results
5 people found this helpful
This has greatly reduced my high blood pressure and cholesterol! I discovered it through my brother and, due to a chaotic work schedule, I struggled with nutrition. NAC Detox Regulators have proven to be the best option. I have been taking it daily for a year, and my health reports show significant improvement in my blood pressure and cholesterol. I highly recommend it – it has genuinely improved my life.
Read More
9
Natto benefits
Great! Excellent quality and dosage. I recommend it to everyone, especially those dealing with blood clots or thrombosis. Natto significantly "gnaws" at blood clots, though large dosages are required over a prolonged period.
Read More
7.5
Optimises blood condition
I faced blood vessel issues following Covid, so I occasionally take this product. The dosage is optimal, and the quality exceeds expectations. It helps break up bioclogging and removes excessive sputum, effectively thinning it.
Read More
7.5
Liver and lung protection
This product is essential for recovery after Covid and various viruses. It protects the liver from alcohol and drug effects, and the lungs from tobacco carcinogens. It normalises blood pressure and reduces cholesterol while aiding in expelling phlegm from a persistent cough. It also assists with allergies and respiratory issues.
A blood clot is a mass of blood that changes from a liquid to a gel, effectively forming a plug that can stop bleeding. This natural process, known as coagulation, is critical for preventing excessive blood loss when you sustain an injury. Blood clots can occur in various areas of the body, typically at the site of a wound, but they can also form within blood vessels without an obvious injury, which may lead to serious health complications.
While blood clots are essential for healing, they can pose significant health risks if they form inappropriately. For example, a deep vein thrombosis (DVT) occurs when a clot forms in a deep vein, usually in the legs, and can travel to the lungs, causing a life-threatening condition called a pulmonary embolism. Risk factors for blood clots include prolonged immobility, certain medical conditions, and the use of specific medications, among others. It’s important to recognize the symptoms of abnormal clotting, such as swelling, pain, and redness in the affected area, and seek medical attention if they occur.
N-Acetyl Cysteine (NAC) is a modified form of the amino acid cysteine, known for its role as a powerful antioxidant and mucolytic agent. It has been widely used as a dietary supplement for various health benefits, including supporting respiratory health, detoxification, and enhancing overall immune function. NAC is particularly recognized for its ability to replenish glutathione, one of the body's most important antioxidants, which helps combat oxidative stress and protect cells from damage.
In addition to its antioxidant properties, N-Acetyl Cysteine is commonly leveraged in a clinical setting for its effectiveness in treating acetaminophen (Tylenol) overdoses, as it aids in restoring depleted glutathione levels, thus preventing liver damage. It can also be beneficial for individuals with chronic respiratory conditions, such as COPD or cystic fibrosis, as it helps in thinning mucus, making it easier to expel. While NAC is generally considered safe for most people, it’s important to consult a healthcare professional before starting any new supplement, particularly for those with pre-existing conditions or those already on medication.
Based on user reviews, the timeline for seeing results from taking supplements for blood clots can vary. Some users report significant improvements only after extended periods of usage. For example, one user noted that large dosages are required over a prolonged period to effectively address blood clots, suggesting that patience and consistency are essential in witnessing results (Read Review). Another user indicated the effectiveness of a product and its role in recovery after experiencing blood vessel issues due to Covid, implying a need for regular consumption for optimal results (Read Review).
While specific timelines are not consistently detailed across reviews, many emphasize the importance of ongoing use, suggesting that significant changes may take weeks or longer to fully manifest. Therefore, if you're considering this supplement for blood clots, it may be beneficial to maintain a daily regimen and monitor your progress over time.
Recent research suggests that selenium and selenium-based supplements may offer promising benefits in the context of blood clot prevention and treatment. A study highlighted the use of innovative selenium designs that target blood clots effectively by generating reactive oxygen species under ultrasound, a method that showed impressive results in dissolving clots without the bleeding risks common with traditional therapies [1]. Furthermore, another investigation found that selenium nanoparticles significantly enhance imaging for carotid blood clots, improving diagnosis and potentially aiding in stroke prevention strategies [2].
Studies have consistently demonstrated that selenium has a positive effect on platelet activity, with several showing that selenium supplementation can lower risks associated with blood clots. One randomized study reported lower levels of a urinary marker linked to platelet activity among those taking selenium [4]. Additionally, research on ebselen, a selenium compound, showed its effectiveness in reducing thrombus formation in microvessels [5]. While the overall evidence is compelling, it suggests that the benefits of selenium supplements for blood clot prevention may depend on individual health conditions and dietary intake [7]. Thus, while selenium shows potential, more extensive real-world studies are needed to fully understand its therapeutic applications.
Users have reported a variety of positive improvements in their symptoms after using certain supplements aimed at managing blood pressure, cholesterol, and blood sugar levels. For instance, one user successfully halted their blood sugar medication, maintaining fasting blood sugar levels below 6 after combining NAC and cinnamon, which they highly recommend for others facing similar challenges (Read Review). Additionally, another reviewer noted significant reductions in both blood pressure and cholesterol after a year of consistent use, crediting NAC Detox Regulators as a major factor in their health improvement (Read Review).
Moreover, users dealing with recovery from Covid have shared their experiences with products that not only helped clear respiratory issues but also appeared to assist in normalizing blood pressure and enhancing overall health (Read Review). It's crucial to remember that while these anecdotal experiences are encouraging, individual results can vary significantly. Some users, for example, did report side effects such as fatigue and nausea, underscoring the need for caution and individual assessment when introducing any supplement into your regimen (Read Review).
Users have reported positive outcomes when combining specific supplements to manage blood clots. One user highlighted the effectiveness of Natto, stating that it significantly "gnaws" at blood clots but requires large dosages over an extended period to fully achieve results (Read Review). This suggests that patience and consistency are key when incorporating Natto into a regimen aimed at managing blood clots. Additionally, users recovering from Covid noted that certain products not only supported their lungs and general health but also effectively thinned mucus and potentially contributed to overall blood circulation health (Read Review).
While many users have shared favorable experiences regarding their supplement combinations, caution is advised. Some report side effects like fatigue and nausea, prompting important considerations about individual reactions to these supplements (Read Review). Therefore, when integrating multiple supplements, especially those targeting blood clots or cardiovascular health, individuals should monitor their responses closely and consult healthcare professionals when necessary.
Based on user reviews, there isn't a consensus on a specific dosage of N Acetyl Cysteine (NAC) for treating blood clots. However, several users do emphasize that effective results are often linked to larger dosages taken over an extended period. One user noted, "large dosages are required over a prolonged period" to help in addressing blood clots and thrombosis Read Review. Another added that the product's dosage is optimal and helps manage blood vessel issues following Covid, indicating satisfaction with its performance Read Review.
Moreover, users highlight the product's additional benefits, such as managing blood pressure and cholesterol levels while also aiding in detoxification, which could indirectly support blood health. One review expresses significant improvement in health metrics after taking NAC for a year, although it does not specify the dosage used Read Review. Overall, while users report positive experiences with NAC for health improvements related to blood clots, specific dosage recommendations remain vague and appear to vary across individual circumstances.
9
Natto benefits
Great! Excellent quality and dosage. I recommend it to everyone, especially those dealing with blood clots or thrombosis. Natto significantly "gnaws" at blood clots, though large dosages are required over a prolonged period.
7.5
Optimises blood condition
I faced blood vessel issues following Covid, so I occasionally take this product. The dosage is optimal, and the quality exceeds expectations. It helps break up bioclogging and removes excessive sputum, effectively thinning it.
9
Blood sugar control
It has a considerable impact on managing blood sugar and has been repurchased multiple times. By taking NAC and cinnamon together, I have halted blood sugar medication and maintained my fasting blood sugar below 6. Highly recommended.
9
Life-changing results
5 people found this helpful
This has greatly reduced my high blood pressure and cholesterol! I discovered it through my brother and, due to a chaotic work schedule, I struggled with nutrition. NAC Detox Regulators have proven to be the best option. I have been taking it daily for a year, and my health reports show significant improvement in my blood pressure and cholesterol. I highly recommend it – it has genuinely improved my life.
7.5
Liver and lung protection
This product is essential for recovery after Covid and various viruses. It protects the liver from alcohol and drug effects, and the lungs from tobacco carcinogens. It normalises blood pressure and reduces cholesterol while aiding in expelling phlegm from a persistent cough. It also assists with allergies and respiratory issues.
4
Blood pressure relief
1 people found this helpful
I used it, and my blood pressure significantly decreased. However, I became very tired, and my son tried it twice but vomited. Exercise caution with this product.
9.5
Selenium-based therapy shows promise
Bionanoengineered 2D monoelemental selenene for piezothrombolysis.
We explored a new approach to treat blood clots using piezoelectric selenene. This study introduced a unique design that combines selenene with platelet membranes, enhancing its ability to target thrombosis.
Under ultrasound, the selenene generates reactive oxygen species, effectively dissolving clots without the bleeding risks associated with traditional therapies.
In both lab and live animal tests, these selenium-based nanosheets demonstrated impressive results, outperforming a standard clinical drug. It's a promising step toward safer, more effective treatments for thrombosis.
8
Enhanced imaging for carotid thrombosis
High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging.
We investigated how selenium-based nanomaterials boost photoacoustic imaging to identify carotid artery blood clots more effectively. By using a thrombosis model in mice, we found that these nanocomposites significantly enhanced imaging signals—up to 5 times greater—which helps diagnose the extent of carotid atherosclerosis.
This research suggests that selenium/polypyrrole nanoparticles may be a promising tool for improving the detection and diagnosis of carotid thrombosis, potentially leading to better stroke prevention strategies.
7
Antioxidants may aid cardiovascular health
Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites.
We explored how low-dose antioxidant supplements affect urinary markers linked to blood clotting and cardiovascular health. In this randomized, double-blind, placebo-controlled study with 186 healthy volunteers, one group received supplements while the other received a placebo for two years.
Our findings show that participants who took the multi-antioxidants had significantly lower levels of a specific urinary marker associated with platelet activity. Notably, selenium was particularly linked to these results, suggesting it can help reduce clot formation, which might support heart health.
9.5
Ebselen delays blood clot formation
Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression.
We explored the effects of ebselen, a selenium compound known for its antioxidant properties, on blood clot formation in rats. Our study demonstrated that ebselen significantly delayed thrombus formation in microvessels.
In particular, animals treated with ebselen showed a marked delay in vessel occlusion compared to those treated with a control substance. In most cases, ebselen entirely prevented blood clot formation in arterioles.
This suggests that ebselen can be effective in reducing the risk of blood clots, particularly in situations characterized by oxidative stress.
7
Selenium may reduce blood clot risk
[Selenium, glutathione peroxidase, peroxides and platelet functions].
We explored the role of selenium in blood clotting, particularly its impact on platelets in people who are selenium-deficient. This research highlights how selenium helps manage the activity of glutathione peroxidase, an important enzyme in the body.
When selenium levels are low, platelets tend to become overly active, leading to increased clotting risks. However, we observed that selenium supplementation can enhance the activity of this enzyme, reducing platelet aggregation and potentially lowering the chances of thrombosis and heart disease.
About 10% of the population in France is selenium-deficient, so increasing selenium intake may provide health benefits in preventing vascular issues for these individuals.
References
Hu H, Xia L, Wang J, Huang X, Zhao Q, et al. Bionanoengineered 2D monoelemental selenene for piezothrombolysis. Biomaterials. 2024;305:122468. 10.1016/j.biomaterials.2024.122468
He F, Hou W, Lan Y, Gao W, Zhou M, et al. High Contrast Detection of Carotid Neothrombus with Strong Near-Infrared Absorption Selenium Nanosphere Enhanced Photoacoustic Imaging. Int J Nanomedicine. 2023;18:4043. 10.2147/IJN.S404743
Mondal A, Douglass M, Hopkins SP, Singha P, Tran M, et al. Multifunctional Nitroso--acetylpenicillamine-Incorporated Medical-Grade Polymer with Selenium Interface for Biomedical Applications. ACS Appl Mater Interfaces. 2019;11:34652. 10.1021/acsami.9b10610
Arnaud J, Bost M, Vitoux D, Labarère J, Galan P, et al. Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites. J Am Coll Nutr. 2007;26:405.
Lindenblatt N, Schareck W, Belusa L, Nickels RM, Menger MD, et al. Anti-oxidant ebselen delays microvascular thrombus formation in the rat cremaster muscle by inhibiting platelet P-selectin expression. Thromb Haemost. 2003;90:882.
Ricetti MM, Guidi GC, Tecchio C, Bellisola G, Rigo A, et al. Effects of sodium selenite on in vitro interactions between platelets and endothelial cells. Int J Clin Lab Res. 1999;29:80.
Vitoux D, Chappuis P, Arnaud J, Bost M, Accominotti M, et al. [Selenium, glutathione peroxidase, peroxides and platelet functions]. Ann Biol Clin (Paris). 1996;54:181.
Herrick AL, Rieley F, Schofield D, Hollis S, Braganza JM, et al. Micronutrient antioxidant status in patients with primary Raynaud's phenomenon and systemic sclerosis. J Rheumatol. 1994;21:1477.
Perona G, Schiavon R, Guidi GC, Veneri D, Minuz P. Selenium dependent glutathione peroxidase: a physiological regulatory system for platelet function. Thromb Haemost. 1990;64:312.